Inevitability or ... a guide to action? Why do we age? Why does our body at some point though is losing the taste for life and ceases to work in a familiar rhythm? And why do some come to this sooner, while others like "charm", and, it seems, does not impose its imprint or their soul or their body? I think that no one person who would not ever ask such a question, but biologists, doctors and sociologists for several hundred years trying to unravel the greatest mystery of this life.

It is clear that the answers must be sought at the deepest levels – the living cell, or more precisely – its metabolic processes. For a long time scientists have demonstrated that the cell has a "stitching" program of death, in other words, we show that cell death is predetermined genetically, and at some point it will be launched – the inexorable process of aging begins in our body as only the amount of cell death begins to dominate over the processes of fission and regeneration. But what started this program? What specific factors may accelerate, and any delay or at least slow down the "biological clock"? Other words, we must understand: who are our friends and enemies. On the enemy: As with any enemies, they are divided into external and internal. External Methods of combating environmental degradation, increased number of aggressive factors

The choice of clean areas, regular intake of vitamins and antioxidants that protect the body during periods of high loads excessive UV exposure

Changes related to "chocolate tan, use sunscreen creams, active fotozaschita Chronic stress

Planning and management regime of work and rest Hypodynamy

Fitness increase of cholesterol and sugars in the diet, the use of excess calories Proper selection of diet in the eventual "subversion" external enemies leads to increased internal enemies: hormonal disorders, genetic damage and reduced immunity – all this combined makes our bodies are very unaccustomed to a condition that leads to a malfunction of its systems. The impact of each adverse factor in the human body has been carefully studied: these studies formed the basis of various theories of aging. Theories of aging free-radical theory of aging was proposed by D. Harman in 1954, she devotes a leading role in razregulyatsii cellular activity of free radicals. These high-level chemical agents produced in our body for various reasons: UV and ionizing radiation, inflammatory reactions, etc. A. Comfort provides home the ability of free radicals: a tendency "to connect to anything." That is, we come in contact with the structures of living cells, they behave like "a bull in a china shop", damaging and destroying everything that comes "under the arm. Proper repair mechanisms can not always cope with the damage caused by free radicals, these changes gradually accumulate, and when these cells become too much, your body starts to age. Glikatsii theory proposed Meylardom, "blames" a change in structure and function of cells of sugar, which " attacks the "protein structure of tissues, blood vessels, cell membranes. In 1984 Lopukhin et al suggested that cholesterol theory of aging, according to which over the years, the rate of cell division is reduced, and their membranes accumulate large amounts of cholesterol, which is not spent on "Production of new cells. The cell membrane, "downtrodden" cholesterol to function worse, cell aging. Hormonal theory of aging was developed Dilmanom in 1968. He suggested that aging as a result of violations of the regulatory activity of the pituitary and hypothalamus – brain structures, "orchestrate" the elaboration of all hormones in the body. The author believes that changes in the activity of the hypothalamus leads to the "deregulation" of many parties and exchange functions of the organism. The theory of "accumulation of errors" was first proposed by L. Orgelem (1963). It is based on the assumption that the main cause of aging is the accumulation of genetic damage with age as a result of mutations. In connection with the accumulation of DNA damage genes may simply lose the ability to properly regulate the activity of metabolic processes.As skin ages and how you are getting the external signs of aging? Are there ways to combat them? Today in aesthetic medicine conventionally distinguish two types of aging: biological aging, the first signs of which we see after 40 years of age, and photo-aging caused by ultraviolet radiation, primarily rays of the spectrum A, appearing at a younger age (30-35 years), when the symptoms biological aging barely noticeable. Biological aging occurs in different people about one and the same scenario – this process is genetically predetermined. But as far as our skin will be exposed to photo-aging, depends more on us. This type of aging is developed, as already stated, under the influence of ultraviolet rays. A classic example: I agree, if you evaluate the condition of the skin, for example, hands and thighs, then you will see that the open areas the signs of aging will be more noticeable. During a lifetime exposure to UV rays is accumulated: the more we sunbathe, the more pronounced will be signs of photo-aging, this is an answer to the question "why some are aging rapidly, and others – slowly." What is the difference between these two processes and what is the difference in approaches to combat them? 1. Biological aging is characterized by thinning of the epidermis, a violation of its barrier function. Reduces the number of active cells capable of synthesizing collagen fibers, elastin and moisture of skin responsible for hyaluronic acid. This is manifested in the relaxation of the skin, its thinning, the formation of a network of wrinkles. If we define a single word the essence of these processes, I would call this extinction. 2. Photoageing – this is an awkward attempt of an organism to maintain internal environment from the destructive action of ultraviolet rays of type A. In the epidermis slows down exclusion of dead cells thickens the stratum corneum, there are abnormal cells that may give rise to tumors. The decline is immunozaschitnye properties of skin. The number and size of pigment cells, which leads to hyperpigmentation. In the dermis accumulates a large number of "disability" elastin fibers: they are not flexible, and can not provide normal elasticity and skin tone. This is reflected in the thickening, coarsening and reduced skin elasticity. The essence of these processes, I would define as Surge regeneration. What is common between these two states? In this and in another case, we are faced with the problem: – violation of the structure of the epidermis and decreased its protective functions, pigmentation disorders – changes of collagen fibers, elastin, and reduce the amount of hyaluronic acid, which is directly related to changes in cellular activity – the deterioration of peripheral circulation. It is clear that no one approach in isolation can not solve all the tasks, so we, as practitioners, prefer comprehensive programs of treatment and prevention of skin aging. But every time we start talking about the treatment of aging, I always want to clearly define therapy as such, and correction of aesthetic defects of the skin, occurring as a manifestation of the underlying processes of aging. In my opinion, we have the right to talk about aging therapies, when used methods not only lead to an improvement of skin appearance of the patient, but also accompanied by real changes in its structure and function, change the reduction potential of the skin and change the forecast age-related changes. In other cases, when it is impossible to influence the processes that caused the change, but you can adjust the external manifestations, it would be aesthet
ic correction. Components for therapy that can delay or postpone the aging process. Alphahydroxy acid (glycolic acid). Various creams (ask your beautician)-accelerated exfoliation Modified Peeling, which can be done in the salon Sweet skin system, New youth, Mene & Moy, etc.-whitening and smoothing the skin, lifting and improving skin tone due to the stimulation of metabolism in the dermis of Vitamin A and its derivatives. creams or a professional peel Yellow peel-accelerated cell division and exfoliation.AntioksidantyyuKremy, serum-protection of cells and fibers of the dermis from damage by free radicals and slows down photo-aging, protection pigmentoobrazuyuschih cells melanocytes and the normalization of pigmentation Hyaluronic kislotayuKremy, injection preparations, the technique biorevitalisation (IAL-System, AcHyal)-toning and skin turgor, hydration, Vitamin C (ascorbic acid, askorbilfosfatmagniya). creams, serums, mezoterapevticheskoe introduction-oxidant effect. Methods aesthetic correction that can "retouch" the outward manifestations of aging Skin median and deep. Peelings using trichloroacetic acid and phenol various concentrations. Botox small and decrease the depth of wrinkles. Preparations of botulinum toxin. Injecting drugs Botox, Dysport. Wrinkle appearing Preparations for contour plasty ("fillers"). Injection. Correction of shape, contour and volume of the lips, cheeks and chin. Injections of polymers of lactic acid. Injectable Products New Fill. Creating additional capacity in the tissues. And it's not all! It is clear that it is impossible to tell in a small review of all procedures that we use for the treatment of aging skin, it requires a number of publications. Here we are told only of the most frequently used and studied therapeutic methods and deliberately did not address the topic of surgical approaches. In conclusion, we can say that now spend an enormous amount of research, developed innovative technologies aging therapy: new cellular technology in the near future, we hope, enable us to "replace" aging cells of the body at the young, new drugs for implantation would not only "fill in" missing volume under the wrinkle, but also to recreate the structure of normal skin, and injections of botulinum toxin completely give way to no less effective cream. I hope that soon, giving the definition of the concept of "aging", we can say that it is the accumulation of different absolute Reversible age-related changes in cells and tissues. The magazine "News in the cosmetics industry" Author: Elena Tubinis, the cosmetic dermatologist doctor